«La société de technologie médicale Sensodetect fait état de résultats encourageants issus de son étude clinique sur le trouble du spectre autistique (ASD) menée en Arabie Saoudite. Selon l'entreprise, les premières données confirment la faisabilité de sa méthode ainsi que le bon fonctionnement du processus de mesure tel qu'il a été conçu. En analysant les réponses auditives du tronc cérébral (ABR), SDD fournit des données objectives venant compléter les évaluations comportementales traditionnelles.» [...]
« « Cette étude représente une étape majeure vers la révolution du diagnostic de l'ASD », déclare le directeur général PA Hedin dans un communiqué de presse. « Ce qui est important, et qui ne figure pas dans l'analyse intermédiaire, c'est que notre modèle d'intelligence artificielle affiche déjà de bons résultats pour détecter les biomarqueurs spécifiques à l'ASD -- ce qui viendra encore améliorer les résultats finaux lorsque nous intégrerons des données locales supplémentaires en provenance d'Arabie Saoudite », ajoute PA Hedin. »...

«Early-onset neonatal sepsis is associated with an increased likelihood of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), although the association with ADHD is attenuated in sibling-matched analyses, according to a study published online June 18 in Paediatric and Perinatal Epidemiology.»...

«Early-onset neonatal sepsis is associated with an increased likelihood of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), although the association with ADHD is attenuated in sibling-matched analyses, according to a study published online June 18 in Paediatric and Perinatal Epidemiology.»...

«IntroductionInfancy and early childhood are the key stage for the rapid development of brain structure and function, and brain development at this stage has a profound impact on the future intelligence, behavior and health of individuals. A growing body of research suggests that maternal inflammation, as a potential environmental factor, may affect brain development in infants and young children through a variety of mechanisms. Therefore, it is of great significance to evaluate the risk of maternal inflammation to early brain development in infants and young children in infants and young children based on multi-source data modeling to understand the mechanism of early development and prevent brain development disorders.»...

«A la recherche de thérapies ciblées Après avoir étudié la médecine à l'UNIGE, Michel Godel s'est attelé à faire un doctorat en neurosciences à l'école doctorale lémanique de neurosciences (LNDS) dans le laboratoire de Marie Shaer, Professeure au Département de Psychiatrie de la FacMed et membre du Centre Synapsy. Pendant les quatre années de son doctorat, Michel Godel s'est consacré à l'étude du développement du langage chez les enfants atteints de trouble du spectre de l'autisme (TSA), dans le but d'identifier différents sous-groupes.»
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«En combinant plusieurs méthodes d’analyse telles que l’électroencéphalogramme pour observer l’activité cérébrale, l’imagerie par résonance magnétique (IRM) pour évaluer la maturation du cerveau, ainsi que des mesures portant sur la voix, le vocabulaire et la grammaire, il a pu démontrer l’existence, dès le plus jeune âge, de sous-groupes autistiques, caractérisés par des trajectoires spécifiques d’acquisition du langage. Ces avancées ouvrent la voie à des interventions mieux adaptées aux profils individuels des enfants. »...

«What Brings Autistic People Joy?New research showcases the diversity in autistic flourishing. Key points - Autistic people report experiencing intense joy in ways connected to autistic traits.

• Passionate interests, deep focus and learning, and sensory experiences can bring profound joy.
•The biggest barriers to autistic joy are mistreatment by other people and societal biases, not autism itself.» [...]
«The Study: Listening to Autistic Voices Elliot Wassell surveyed 86 autistic adults through an autism charity's online community. Rather than focusing on deficits or challenges, this study centered autistic people's own experiences of what makes them happy. The majority of participants were women and non-binary people, an often underrepresented group in autism research. While the sample has limitations, it nevertheless challenges us to recognize joy wherever it appears rather than overlooking it because of label-based expectations. »...

«Planning an autistic child's occupational therapy is usually a conversation between their parents and a therapist. But a University of Missouri study found children could benefit from taking part in those conversations.Occupational therapy is used to promote, maintain and develop everyday skills. Each occupational therapy session is tailored to what the patient wants to work on. Melanie Tkach, a University of Missouri researcher, occupational therapist, and assistant professor in the College of Health Sciences, conducted the study, which gives autistic children more agency in planning their therapy while also getting to stay in the comfort of their own home.The study involved 17 children between the ages of five and 13. It took place over the course of eight sessions...”with the exception of one family, who met their goals in seven.Tkach believes that the breakthroughs she saw in the children are because they were involved in their planning.»...

«A board game through which players use images on cards to develop and tell their own stories could be particularly appreciated among people with autism as it offers a means to explain their thoughts and feelings, a new study has shown.Dixit, an award-winning game published by the French company Libellud, invites participants to select one of 84 illustrated cards which they feel matches a title suggested by the designated storyteller.For this study, researchers asked 35 autistic participants...”split into groups of between five and eight...”to place a card that they felt best described autism, and then were asked to explain the reasoning for their choices.»...

«AbstractThe gut microbiome significantly influences physical and mental health, including the synthesis and metabolism of hormones and the detoxification of heavy metals, which are linked to behavioural disorders. This study investigated the associations of these biological factors with the behaviour of primary school children, specifically examining the effects of heavy metals, catecholamines, and microbiome-associated metabolites of dopamine, noradrenaline, adrenaline, and thyroxine precursors. Urine samples from 87 unselected primary school children were analysed to assess heavy metal load (arsenic, cadmium, lead, mercury), noradrenaline/adrenaline ratio, and microbiome-associated metabolites of phenylalanine, tyrosine and L-dopa (3-phenylpropionic acid, p-OH-phenylacetic acid, 4-hydroxybenzoic acid, 3,4-dihydroxyphenylpropionic acid). Three months later, executive functions, ADHD symptoms (inattention, hyperactivity and impulsivity), and social behaviour were evaluated via parent and teacher questionnaires. In a path model, heavy metal load, microbiome-associated metabolites, and the noradrenaline/adrenaline ratio measured in urine accounted for 32% of social behaviours. Microbiome-associated metabolites predicted 11% of the variance in executive functions and 17% in ADHD symptoms. Executive functions shared 55% of the variance with ADHD symptoms and 17% with social behaviours. Children with the lowest social behaviours had a sixfold increase in the odds of high heavy metal loads and a 3.4-fold increase in the odds of elevated microbiome-associated metabolites. Similarly, children with the most compromised executive functions had a threefold increase in the odds of such high metabolite levels.»
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« Overall, the results indicate that children’s social behaviours are influenced by heavy metal accumulation, catecholamine balance, and the microbiome-associated metabolism of amino acids, that are crucial for producing stress and thyroid hormones. »...

«Abstract This study examines the influence of temperature and noise on autistic individuals. Conventional indoor comfort questionnaires as well as pre-validated attentional tests were administered to autistic and typically developed individuals across six different environmental scenarios. Results showed that autistic individuals struggled with completing conventional questionnaires independently providing inconsistent responses. Attentional tests were always successfully autonomously completed, revealing significant performance declines for autistic individuals because of temperature variation (4 °C) or sudden noises. Background noise (55 dB(A)) also caused performance decreases, whether typically developed individuals were unaffected by all conditions. These findings suggest that (i) conventional indoor comfort questionnaires are unsuitable for autistic individuals, (ii) indoor environmental conditions (temperature and noise) do stress autistic people (iv) stressors thresholds are provided and (iv) attentional tests could be successfully used to investigate autistic individuals' indoor conditions and assess their perceived stress in relation to variations of temperature and acoustic circumstances.»...

«A new study published in The Journal of Infectious Diseases showed that food allergies, asthma, allergic rhinitis, and cognitive impairment were more common in children who had several antibiotic courses before the age of two.Antibiotics are among the most life-saving medicinal therapies and one of the greatest medical breakthroughs. Their extensive usage, which is occasionally unreasonable or even improper, is a result of their effectiveness and assumed safety. Antibiotics are among the most often prescribed medications for babies and toddlers.»...

«Il préfère le mail au téléphone. Il a toujours eu « du mal dans les interactions sociales ». A Brest (Finistère), Jean Vinçot a décidé, il y a deux ans, de lever le doute sur ce qu'il appelle ses « bizarreries ». Il témoigne.Depuis 20 ans, Jean Vinçot, père d'une fille autiste, est investi dans l'association brestoise pour la Sensibilisation à la protection, l'éducation et la recherche sur l'autisme, et notamment le syndrome d'Asperger (Asperansa). Une connaissance du handicap qui l'a amené à s'interroger sur lui-même et à solliciter l'avis d'un médecin à 70 ans.»...

«A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) glutamate receptor, which is key to regulating excitatory synapse function in the brain. This achievement paves the way for the precise control of excitatory synapse function in specific neural circuits and may provide important clues for developing treatments for brain diseases such as autism spectrum disorders.The study is published in the journal Progress in Neurobiology. The team was led by DGIST Professors Ko Jaewon and Um Ji Won of the Center for Synapse Diversity and Specificity in the Department of Brain Sciences Professor Ko commented, "The MDGA2 protein is highly associated with various brain developmental diseases, such as autism spectrum disorders. Surrounding proteins, including EphB2, are also highly relevant, so we will expand our research to preclinical studies."»
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«Professor Um remarked, "This study confirms our previous model that the MDGA2 protein acts as a conductor that coordinates the function of excitatory synapses by interfering with key synaptic adhesion proteins that are completely different structurally." Professor Ko commented, "The MDGA2 protein is highly associated with various brain developmental diseases, such as autism spectrum disorders. Surrounding proteins, including EphB2, are also highly relevant, so we will expand our research to preclinical studies." »...

«Psychology researchers from The University of Texas at Dallas are challenging the perception that the difficulties autistic people face in socializing are due to one-sided deficiencies.Sarah Foster, a psychology doctoral student in the School of Behavioral and Brain Sciences, is the corresponding author of a study published online Feb. 24 in the journal Autism that examines four-person group interactions among neurotypical, autistic and mixed groups of individuals."Many researchers have framed autistic people as having empathy deficits, or lacking social motivation or skill," Foster said. "We believe that these are not deficits, but differences often arising from a mismatch in communication styles and ways of thinking. Shifting the focus to a relational framework can make a significant difference ...” not only in reducing stigma, but also in more accurately capturing the nuances of social interactions."Her findings offer further support for the theory of the "double empathy problem," which posits that social difficulties between autistic and nonautistic people often stem from mutual misunderstandings, rather than a one-sided deficit.»...

«Le gouvernement veut déployer la CAA, qui permet aux personnes qui ne peuvent pas parler, à cause d'un handicap ou d'une maladie, de s'exprimer par des pictos, signes ou outils technologiques.»...

«Le gouvernement veut déployer la CAA, qui permet aux personnes qui ne peuvent pas parler, à cause d'un handicap ou d'une maladie, de s'exprimer par des pictos, signes ou outils technologiques.»...

«Understanding the history of ASD may help us understand its increased prevalence KEY POINTS. As misinformation about autism increases, knowing its real history and research is pivotal.Autism was once separate, but autism now includes Aspergers and other pervasive developmental disorders.Increased prevalence of autism is due to merging diagnoses, genetic drift, and increased awarenessPoliticians and the media always like simple, curable answers to autism, but the research shows differently.»...

«Immune molecules called cytokines play important roles in the body's defense against infection, helping to control inflammation and coordinating the responses of other immune cells. A growing body of evidence suggests that some of these molecules also influence the brain, leading to behavioral changes during illness.Two new studies from MIT and Harvard Medical School, focused on a cytokine called IL-17, now add to that evidence. The researchers found that IL-17 acts on two distinct brain regions ...” the amygdala and the somatosensory cortex ...” to exert two divergent effects. In the amygdala, IL-17 can elicit feelings of anxiety, while in the cortex it promotes sociable behavior.»...

«Longtemps considéré comme une pathologie à forte composante génétique, l'autisme pourrait en réalité résulter d'une interaction bien plus complexe entre gènes et environnement. C'est ce que défendent les chercheurs Yehezkel Ben-Ari, neuroscientifique de renommée mondiale, et Etienne E. Danchin, directeur de recherche émérite au CNRS, dans une étude récemment publiée dans le Journal of Medical Genetics. Selon eux, il est urgent de réévaluer le poids des facteurs environnementaux prénatals dans l'émergence des troubles du spectre autistique (TSA) et de revoir en profondeur les stratégies de dépistage et de prise en charge.»...

«MONTREAL ...” Un dérèglement du mécanisme de transport du calcium dans le cerveau pourrait être associé à l'autisme et à la déficience intellectuelle, démontrent des travaux effectués à l'Université McGill.Ces conclusions chamboulent une croyance bien implantée chez les neuroscientifiques et pourraient ouvrir la voie à de nouveaux traitements, assure-t-on.«Ã‡a change complètement notre compréhension du fonctionnement du cerveau, a dit le professeur Derek Bowie, de l'Ecole des sciences biomédicales de McGill. On a maintenant une sorte de structure, de « framework », pour comprendre comment fonctionne l'autisme.»Le professeur Bowie et son équipe ont constaté, contrairement à ce que l'on croyait, que des structures cérébrales connues sous le nom de récepteurs AMPA peuvent transporter du calcium, et qu'elles sont même très efficaces à le faire.»...